Topics Molecular Medicine

Molecular Medicine


1.  Role of FoxO1 transcription factor in B-cell malignancies

​Supervisor: Prof. MUDr. Mgr. Marek Mráz, Ph.D.; Research group: Microenvironment of Immune Cells

Keywords:  CLL, FoxO1, targeted therapy, microenvironment, apoptosis

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2.  Long non-coding RNAs (IncRNAs) in the pathogenesis of mature B cell malignancies

​Supervisor: Prof. MUDr. Mgr. Marek Mráz, Ph.D.; Research group: Microenvironment of Immune Cells

Keywords: Long non-coding RNA, lymphomas, DLBCL, miRNA

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3.  Regulation of microenvironmental interactions in chronic lymphocytic leukemia by non-coding RNAs

​Supervisor: Mgr. Miroslav Boudný, Ph.D.; ​Consultant: doc. MUDr. Mgr. Marek Mráz, Ph.D.

Research group: Microenvironment of Immune Cells

Keywords: miRNA, CLL, T cell, microenvironment

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4.   Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression and tumorigenesis

Supervisor: Mgr. Dalibor Blažek, Ph.D.; ​Research groupInherited Diseases - Transcriptional Regulation

Keywords: CDK11, transcription, mRNA processing, RNA polymerase II, cancer, genomics, proteomics, kinase inhibitors

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5.  Characterization of cyclin-dependent kinase 12 (CDK12) substrates and their roles in regulation of transcription and tumorigenesis

Supervisor: Mgr. Dalibor Blažek, Ph.D.; ​Research groupInherited Diseases - Transcriptional Regulation

Keywords:  CDK12, transcription, mRNA processing, RNA polymerase II, cancer, genomics, proteomics, kinase inhibitors

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6 .  Development of bioinformatics methods for radiogenomics approaches in cancer research 

Supervisor: Mgr. Vojtěch Bystrý, Ph.D.; ​Core facility: Bioinformatics Core Facility

Keywords: bioinformatics, radiogenomics, cancer research, genomics, radiomics, spatial transcriptomic

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7.   Role of the transcription factors in onset and progression of B-Cell malignancies

​Supervisor: RNDr. Josef Večeřa, Ph.D.; Research groupMicroenvironment of Immune Cells

Keywords:  CLL, transcription factor, epigenetics, microenvironment

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8.   FoxO transcription factors in lymphoproliferative diseases

Supervisor: Mgr. Václav Šeda, Ph.D.; Research groupMicroenvironment of Immune Cells​

Keywords:  CLL, B cell malignancies, BCR signalling, FoxO1, targeted therapy

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