Topics Molecular Medicine
Molecular Medicine
1. Role of FoxO1 transcription factor in B-cell malignancies
Supervisor: doc. MUDr. Mgr. Marek Mráz, Ph.D.
Keywords: CLL, FoxO1, targeted therapy, microenvironment, apoptosis
2. Regulation of BCR signalling by DNA damage response and P53 protein
Supervisor: Mgr. Miroslav Boudny, Ph.D.
Consultant: doc. MUDr. Mgr. Marek Mráz, Ph.D.
Keywords: BCR signalling, DNA damage response, p53
3. Development of bioinformatics methods for multi-omics approaches in cancer research
Supervisor: Mgr. Vojtěch Bystrý, Ph.D.
RG: Bioinformatics Core Facility
Keywords: bioinformatics, multi-omics, cancer research, genomics, transcriptomics, proteomics
4. Development of bioinformatics methods for radiogenomics approaches in cancer research
Supervisor: Mgr. Vojtěch Bystrý, Ph.D.
RG: Bioinformatics Core Facility
Keywords: bioinformatics, radiogenomics, cancer research, genomics, radiomics, spatial transcriptomics
5. Role of transcription factors in onset and progression of B-cell malignancies
Supervisor: RNDr. Josef Vecera, Ph.D.
RG: Marek Mráz Research Group
Keywords: CLL, transcription factor, epigenetics, microenvironment
6. Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression and tumorigenesis
Supervisor: Mgr. Dalibor Blažek, Ph.D.
RG: Dalibor Blažek Research Group
Keywords: CDK11, transcription, mRNA processing, RNA polymerase II, cancer, genomics, proteomics, kinase inhibitors
Supervisor: Mgr. Dalibor Blažek, Ph.D.
RG: Dalibor Blažek Research Group
Keywords: CDK12, transcription, mRNA processing, RNA polymerase II, cancer, genomics, proteomics, kinase inhibitors
Supervisor: Mgr. Michal Šmída, Dr. rer. nat.
RG: Michal Šmída Research Group
Keywords: Acute myeloid leukemia (AML), targeted therapy, CRISPR/Cas9 screening, precision medicine, therapy resistance