Topics Life Sciences

Life Sciences

1. Characterization of cyclin-dependent kinase 12 (CDK12) substrates and their roles in regulation of transcription and tumorigenesis

Supervisor: Mgr. Dalibor Blažek, Ph.D.   Research group: Inherited Diseases - Transcriptional Regulation 

Keywords: CDK12, transcription, mRNA processing, RNA polymerase II, cancer, genomics, proteomics, kinase inhibitors

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2. Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression and tumorigenesis

Supervisor: Mgr. Dalibor Blažek, Ph.D.  Research group: Inherited Diseases - Transcriptional Regulation 

Keywords: CDK11, transcription, mRNA processing, RNA polymerase II, cancer, genomics, proteomics, kinase inhibitors

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 3. Microenvironment models and their use to study aggressiveness and targeted therapy in B cell malignancies

​Supervisor:  Prof. MUDr. Mgr. Marek Mráz, Ph.D.  Research group: Microenvironment of Immune Cells 

Keywords:   lymphoma, microenvironment, models

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4. Designing modified DNA fragments

​Supervisor: prof. RNDr. Radek Marek, Ph.D.  Research group: Structure of Biosystems and Molecular Materials

Keywords:  DNA, base pairing, molecular modelling, quantum chemistry

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5. Structure of parallel forms of nucleic acids: NMR spectroscopy and molecular modelling

Supervisor: prof. RNDr. Radek Marek, Ph.D.  Research group: Structure of Biosystems and Molecular Materials

Keywords: NMR spectroscopy, DNA, base pairing, molecular modelling.

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6. Dynamic polymorphism of non-canonical nucleic acids in the intracellular space

Supervisor: doc. Mgr. Lukáš Trantírek, Ph.D.  Research group: Non-Coding Genome

Keywords: DNA i-motif; G-quadruplex; gene regulation; in-cell NMR spectroscopy.

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7. Co-translational quality control and its role in neural tissue

Supervisor: RNDr. Petr Těšina, Ph.D.  Research group: Translation Control

Keywords: Translation, cryo-EM, ribosome-associated quality control, co-translational control.

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8. Translation in the context of human host-pathogen interaction

Supervisor: RNDr. Petr Těšina, Ph.D.  Research group: Translation Control

Keywords: Translation, cryo-EM, host-pathogen interaction, co-translational control.

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9. Design of fusogenic peptides

Supervisor: doc. RNDr. Robert Vácha, Ph.D.  Research group: Interaction Protein-Protein and Protein-Membrane

Keywords: Computer simulations, Coarse-grained model, Molecular dynamics, Free energy

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10. Regulation of protein liquid droplets during transcription

Supervisor: doc. RNDr. Robert Vácha, Ph.D.  Research group: Interaction Protein-Protein and Protein-Membrane

Keywords: Computer simulations, Coarse-grained model, Molecular dynamics, Monte Carlo,
Free energy, Sequence motif

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