Topics Life Sciences
Life Sciences
Supervisor: Mgr. Dalibor Blažek, Ph.D. Research group: Inherited Diseases - Transcriptional Regulation
Keywords: CDK12, transcription, mRNA processing, RNA polymerase II, cancer, genomics, proteomics, kinase inhibitors
2. Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression and tumorigenesis
Supervisor: Mgr. Dalibor Blažek, Ph.D. Research group: Inherited Diseases - Transcriptional Regulation
Keywords: CDK11, transcription, mRNA processing, RNA polymerase II, cancer, genomics, proteomics, kinase inhibitors
Supervisor: Prof. MUDr. Mgr. Marek Mráz, Ph.D. Research group: Microenvironment of Immune Cells
Keywords: lymphoma, microenvironment, models
4. Investigating the impact of heat stress on ovule fitness for seed set in Arabidopsis thaliana
Supervisor: Helene Robert Boisivon, Ph.D. Research group: Hormonal Crosstalk in Plant Development Group
Keywords: Arabidopsis thaliana, fertilization, high temperatures
5. Dishevelled internal affairs in Wnt signalling
Supervisor: Konstantinos Tripsianes, Ph.D. Research group: Protein-DNA Interactions
Keywords: Wnt signalling, Dishevelled, Casein kinase, interactions, conformations, phosphorylations, dynamics, allostery, NMR, X-ray crystallography, SAXS, FRET, cryo-EM, native MS, MS-HDX.
6. Deciphering the mechanisms of signal integration via MSP signalling in Arabidopsis thaliana
Supervisor: doc. RNDr. Jan Hejátko, Ph.D. Research group: Functional Genomics and Proteomics of Plants
Keywords: Multistep phosphorelay, cytokinins, ethylene, signal integration, synthetic biology.
Supervisor: Mgr. Vojtěch Bystrý, Ph.D. Core facility: Bioinformatics Core Facility
Keywords: Bioinformatics, long-read sequencing, nanopore technology, structural variant detection, splice variant estimation, direct RNA sequencing, post-transcriptional modification detection, epitranscriptomics.
8. Co-translational quality control and its role in neural tissue
Supervisor: RNDr. Petr Těšina, Ph.D. Research group: Translation Control
Keywords: Translation, cryo-EM, ribosome-associated quality control, co-translational control.
9. Translation in the context of human host-pathogen interaction
Supervisor: RNDr. Petr Těšina, Ph.D. Research group: Translation Control
Keywords: Translation, cryo-EM, host-pathogen interaction, co-translational control.
10. The role of RNA modifying factors in human cancer
Supervisor: Prof. Mgr. Štěpánka Vaňáčová, Ph.D. Research group: RNA Quality Control
Keywords: RNA modifications, RNA processing, transcriptomics, proteomics, protein-RNA interactions
11. Terminal RNA modifications in gene expression and viral infection
Supervisor: Prof. Mgr. Štěpánka Vaňáčová, Ph.D. Research group: RNA Quality Control
Keywords: RNA modifications, RNA processing, transcriptomics, proteomics, protein-RNA interactions
12. Peptide Sequence Motifs for Selective Targeting of Pathogens
Supervisor: doc. RNDr. Robert Vácha, Ph.D. Research group: Interaction Protein-Protein and Protein-Membrane
Keywords: Computer simulations, Molecular dynamics, Free energy, Peptides, Sequence motif
13. Regulation of protein liquid droplets during transcription
Supervisor: doc. RNDr. Robert Vácha, Ph.D. Research group: Interaction Protein-Protein and Protein-Membrane
Keywords: Computer simulations, Coarse-grained model, Molecular dynamics, Monte Carlo,
Free energy, Sequence motif
14. RNA condensates in plant stress adaptation
Supervisor: Mgr. Karel Říha, Ph.D. Research group: Plant Molecular Biology
Keywords: cytoplasmic RNA condensates, plant adaptation, abiotic stress
15. Deciphering the Argonaute Loading Mechanisms in RNA-Silencing Pathways
Supervisor: prof. Mgr. Richard Štefl, Ph.D. Research group: Structural Biology of Gene Regulation
Keywords: gene silencing, small RNA, Argonaute, cryoEM, structures
16. Investigating the Role of Short Regulatory Elements in Plant Sexual Reproduction
Supervisor: Mgr. Petra Procházková Schrumpfová, Ph.D. Research group: Chromatin Molecular Complexes
Keywords: gene regulatory sequences, transcriptional regulation, gametophyte development, genomics, proteomics, plants